Positioning Children’s Voice in Clinical Trials Research: A New Model for Planning, Collaboration, and Reflection

Following the United Nations Convention on the Rights of the Child, there has been considerable growth in research with children about health and services that affect them. Creative methods to engage with children have also been developed. One area where progress has been slower is the inclusion of children’s perspectives in qualitative research in the context of clinical trials or feasibility studies. Addressing this gap, this article discusses experiences of, and reflections on, the process of researching children’s views as part of a clinical feasibility study. The article considers what worked well and highlights remaining dilemmas. A new continuum of children’s engagement in research is presented, designed to assist researchers to make explicit the contingent demands on their research, and to suggest a range of techniques from within the broader fields of health, childhood studies, and education research that could be used to forward qualitative research in clinical contexts

Discovery of a 3.6-hr Eclipsing Luminous X-Ray Binary in the Galaxy NGC 4214

We report the discovery of an eclipsing X-ray binary with a 3.62-hr period within 24" of the center of the dwarf starburst galaxy NGC 4214. The orbital period places interesting constraints on the nature of the binary, and allows for a few very different interpretations. The most likely possibility is that the source lies within NGC 4214 and has an X-ray luminosity of up to 7 e38 ergs/s. In this case the binary may well be comprised of a naked He-burning donor star with a neutron-star accretor, though a stellar-mass black-hole accretor cannot be completely excluded. There is no obvious evidence for a strong stellar wind in the X-ray orbital light curve that would be expected from a massive He star; thus, the mass of the He star should be <3-4 solar masses. If correct, this would represent a new class of very luminous X-ray binary -- perhaps related to Cyg X-3. Other less likely possibilities include a conventional low-mass X-ray binary that somehow manages to produce such a high X-ray luminosity and is apparently persistent over an interval of years; or a foreground AM Her binary of much lower luminosity that fortuitously lies in the direction of NGC 4214. Any model for this system must accommodate the lack of an optical counterpart down to a limiting magnitude of 22.6 in the visible.Comment: 7 pages, ApJ accepted versio

A Study of the Shortest-Period Planets Found With Kepler

We present the results of a survey aimed at discovering and studying transiting planets with orbital periods shorter than one day (ultra--short-period, or USP, planets), using data from the {\em Kepler} spacecraft. We computed Fourier transforms of the photometric time series for all 200,000 target stars, and detected transit signals based on the presence of regularly spaced sharp peaks in the Fourier spectrum. We present a list of 106 USP candidates, of which 18 have not previously been described in the literature. In addition, among the objects we studied, there are 26 USP candidates that had been previously reported in the literature which do not pass our various tests. All 106 of our candidates have passed several standard tests to rule out false positives due to eclipsing stellar systems. A low false positive rate is also implied by the relatively high fraction of candidates for which more than one transiting planet signal was detected. By assuming these multi-transit candidates represent coplanar multi-planet systems, we are able to infer that the USP planets are typically accompanied by other planets with periods in the range 1-50 days, in contrast with hot Jupiters which very rarely have companions in that same period range. Another clear pattern is that almost all USP planets are smaller than 2 $R_\oplus$, possibly because gas giants in very tight orbits would lose their atmospheres by photoevaporation when subject to extremely strong stellar irradiation. Based on our survey statistics, USP planets exist around approximately $(0.51\pm 0.07)\%$ of G-dwarf stars, and $(0.83\pm 0.18)\%$ of K-dwarf stars.Comment: 20 pages, 10 figures. Submitted to ApJ. This version has been reviewed by a refere

Departure from Axisymmetry in Planetary Nebulae

Many planetary nebulae (PNe) exhibit distinctly non-axisymmetric structure in either (i) the shape of the nebula, or (ii) in the off-centered position of the illuminating star. By examining a large number of well resolved images of PNe we estimate that about 30-50 percents of all PNe exhibit distinctly non-axisymmetric structure. In this paper, we discuss how such departures from axisymmetry can arise from the binary nature of the progenitors of the PNe. The scenarios include (a) relatively close binaries with eccentric orbits, and (b) longer orbital period systems with either circular or eccentric orbits. In order to assess the fraction of PNe whose non-axisymmetric morphologies are expected to arise in binary systems, we have carried out a detailed population synthesis study. The expected deviations from axisymmetry are classified for each binary and the results tabulated. We find that about 25 percents of elliptical and 30-50 percents of bipolar PNe are expected to acquire non-axisymmetric structure from binary interactions.Comment: 15 pages + 4 tables; Submitted to Ap

Cardiac-specific Conditional Knockout of the 18-kDa Mitochondrial Translocator Protein Protects from Pressure Overload Induced Heart Failure.

Heart failure (HF) is characterized by abnormal mitochondrial calcium (Ca2+) handling, energy failure and impaired mitophagy resulting in contractile dysfunction and myocyte death. We have previously shown that the 18-kDa mitochondrial translocator protein of the outer mitochondrial membrane (TSPO) can modulate mitochondrial Ca2+ uptake. Experiments were designed to test the role of the TSPO in a murine pressure-overload model of HF induced by transverse aortic constriction (TAC). Conditional, cardiac-specific TSPO knockout (KO) mice were generated using the Cre-loxP system. TSPO-KO and wild-type (WT) mice underwent TAC for 8 weeks. TAC-induced HF significantly increased TSPO expression in WT mice, associated with a marked reduction in systolic function, mitochondrial Ca2+ uptake, complex I activity and energetics. In contrast, TSPO-KO mice undergoing TAC had preserved ejection fraction, and exhibited fewer clinical signs of HF and fibrosis. Mitochondrial Ca2+ uptake and energetics were restored in TSPO KO mice, associated with decreased ROS, improved complex I activity and preserved mitophagy. Thus, HF increases TSPO expression, while preventing this increase limits the progression of HF, preserves ATP production and decreases oxidative stress, thereby preventing metabolic failure. These findings suggest that pharmacological interventions directed at TSPO may provide novel therapeutics to prevent or treat HF

Multi-Color Light Curves of Type Ia Supernovae on the Color-Magnitude Diagram: a Novel Step Toward More Precise Distance and Extinction Estimates

We show empirically that fits to the color-magnitude relation of Type Ia supernovae after optical maximum can provide accurate relative extragalactic distances. We report the discovery of an empirical color relation for Type Ia light curves: During much of the first month past maximum, the magnitudes of Type Ia supernovae defined at a given value of color index have a very small magnitude dispersion; moreover, during this period the relation between $B$ magnitude and $B-V$ color (or $B-R$ or $B-I$ color) is strikingly linear, to the accuracy of existing well-measured data. These linear relations can provide robust distance estimates, in particular, by using the magnitudes when the supernova reaches a given color. After correction for light curve strech factor or decline rate, the dispersion of the magnitudes taken at the intercept of the linear color-magnitude relation are found to be around 0$^m$.08 for the sub-sample of supernovae with \BVm $\le 0^m.05$, and around 0$^m$.11 for the sub-sample with \BVm $\le 0^m.2$. This small dispersion is consistent with being mostly due to observational errors. The method presented here and the conventional light curve fitting methods can be combined to further improve statistical dispersions of distance estimates. It can be combined with the magnitude at maximum to deduce dust extinction. The slopes of the color-magnitude relation may also be used to identify intrinsically different SN Ia systems. The method provides a tool that is fundamental to using SN Ia to estimate cosmological parameters such as the Hubble constant and the mass and dark energy content of the universe.Comment: ApJ, in pres

Transits and Occultations of an Earth-Sized Planet in an 8.5-Hour Orbit

We report the discovery of an Earth-sized planet ($1.16\pm 0.19 R_\oplus$) in an 8.5-hour orbit around a late G-type star (KIC 8435766, Kepler-78). The object was identified in a search for short-period planets in the {\it Kepler} database and confirmed to be a transiting planet (as opposed to an eclipsing stellar system) through the absence of ellipsoidal light variations or substantial radial-velocity variations. The unusually short orbital period and the relative brightness of the host star ($m_{\rm Kep}$ = 11.5) enable robust detections of the changing illumination of the visible hemisphere of the planet, as well as the occultations of the planet by the star. We interpret these signals as representing a combination of reflected and reprocessed light, with the highest planet dayside temperature in the range of 2300 K to 3100 K. Follow-up spectroscopy combined with finer sampling photometric observations will further pin down the system parameters and may even yield the mass of the planet.Comment: Accepted for publication, ApJ, 10 pages and 6 figure